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iimveliso

Exemestane / Aromasin Cancer Unyango Anti Estrogen Steroids for Cutting / Bulking Cycle

Inkcazelo emfutshane:


Iinkcukacha zeMveliso

Iithegi zeMveliso

Iinkcukacha eziKhawulezayo

Exemestane

Isibizo: Aromasin;Exemestan

Imbonakalo: Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe

Umxholo wemveliso: ≥ 99% CAS: 107868-30-4

Ifomula yemolekyuli: C20H24O2

Ubunzima beMolekyuli: 296.40

1

Ukusetyenziswa: isetyenziswe kunyango lomhlaza webele we-metastatic.kwaye isetyenziswe njengoncedo kunyango lomhlaza wamabele kwangoko.

Ungayiva kwakhona ibizwa ngokuba yiAromasin, elona gama lalaziwa kakhulu lebrendi.Kukho inani lezinye iibhrendi ze-exemestane, zonke eziqulethe umthamo ofanayo wechiza.

Iingcebiso zomthamo

Idosi eqhelekileyo yabantu abadala kuMhlaza wamabele:

25 mg ngomlomo kanye ngosuku

Izimvo:

- Eli chiza kufuneka ilawulwe emva kokutya.

Usebenzisa:

- Unyango lwe-Adjuvant lwabasetyhini be-postmenopausal abane-estrogen-receptor positive yomhlaza webele wokuqala abafumene iminyaka emibini ukuya kwemithathu ye-tamoxifen kwaye batshintshelwe kwi-exemestane ukugqitywa kweminyaka emihlanu elandelelanayo yonyango lwe-adjuvant hormonal.

- Unyango lomhlaza webele ophezulu kubasetyhini be-postmenopausal abanesifo esiye saqhubela phambili emva konyango lwe-tamoxifen.

Inkcazo

IAromasin (i-Exemestane acetate) yenye yezo khompawundi zingaqhelekanga ekungekho mntu waziyo ukuba makwenziwe ntoni na.Sisizukulwana sesithathu i-Aromatase Inhibitor (AI) njenge-Arimidex (Anastrozole) kunye ne-Femera (Letrozole).

isizukulwana sesithathu i-aromatase inhibitors, esetyenziswa kunyango lomhlaza webele we-metastatic kwaye isetyenziswa njengoncedo kunyango lomhlaza wamabele kwangoko.

● IAromasin yenye yezona zinto zinamandla zokucinezela i-estrogen.

● I-Aromasin yenye yezona zixhobo zokunciphisa i-aromatizing effect ye-steroids.

● I-Aromasin iyafumaneka kubakhi bomzimba abathatha i-anabolic steroids.

● I-Aromasin ikwabizwa ngokuba yi-Exemestane.

● Isebenza ngokuthintela i-enzyme aromatase, emva koko ivalele ukuveliswa kwe-estrogen.

● I-Aromasin ikwaluhlobo lwe-.antineoplastic (hormonal) ekrwada.

I-Aromasin isetyenziselwa ukulwa nomhlaza webele kunye nokunyusa i-testosterone emzimbeni.

I-Exemestane ivimba inkqubo ye-aromasation.Ngoko ke yehlisa umthamo we-estrogen emzimbeni.Ekuqaleni komhlaza wamabele, ukuthatha i-exemestane kunokunceda ukunqanda umhlaza wamabele ubuye.Kwinqanaba eliphezulu lomhlaza webele iiseli zomhlaza zinokukhula kancinci okanye ziyeke ukukhula ngokupheleleyo.

I-Exemestane yi-aromatase inhibitor.Oku kuthetha ukuba ithintela i-enzyme aromatase (efumaneka kwizihlunu zomzimba, ulusu, ibele kunye namafutha), esetyenziselwa ukuguqula i-androgens (iihomoni eziveliswa ngamadlala e-adrenal) zibe yi-estrogen.Ukungabikho kwe-estrogen, amathumba axhomekeke kule hormone ekukhuleni aya kuncipha

IiNzuzo ze-Exemestane

>>.Ukwakha umzimba

Steroidal Exemestane inhibitor esebenza ngokunciphisa umthamo we-estrogen oveliswa ngumzimba.Isebenza ngokunciphisa ukuguqulwa kwe-Testosterone kwi-estrogen kunye nesantya esiphakathi sokunciphisa i-estrogen yi-85%.Ichiza likwanciphisa amanqanaba e-estradiol malunga ne-50%, kunye nokunyusa kakhulu amanqanaba e-testosterone.

I-Exemestane inhibitor esebenza ngokuthintela ukuhlanganiswa kwe-estrogen.Isebenza ngokunyusa amanqanaba e-Testosterone kunye ne-IGF emzimbeni.Ichiza likwaluncedo kakhulu ngexesha lolawulo lwe-post cycle therapy xa umntu ezama ukubuyisela amanqanaba e-Testosterone yendalo ukuphepha ukuphazamiseka komjikelezo weposi.

>>.Anti-estrogen ichiza

Eyaziwa njengelinye lamachiza abiza kakhulu, i-Exemestane lelinye lamachiza akhuselekileyo achasene ne-estrogen asetyenziswa kakhulu ngabadlali kunye nabakhi bomzimba.Ngokwezonyango iyeza limiselwe ikakhulu kunyango lomhlaza wamabele.Ngokuqhelekileyo ibizwa ngokuba yi-Selective Estrogen Receptor Modulator (SERM), yayisetyenziselwa ngaphambili ukukhusela i-gynocomastia.

Ukusebenza kwe-Exemestane

A)I-Exemestane yokuthintela umhlaza wamabele:

I-Chemoprevention yomhlaza wesifuba sisicwangciso esisebenzayo sokunciphisa iziganeko zesi sifo kwabasetyhini abasengozini.Iiarhente zokuqala zokubonisa umphumo obalulekileyo we-chemopreventive yi-SERMs tamoxifen kunye ne-raloxifen.

Uhlalutyo oluhlaziyiweyo olubanzi lwazo zonke izilingo zokuthintela i-SERM zibonise ukuba ziyakwazi ukunciphisa iziganeko zomhlaza webele kubasetyhini abanomngcipheko ophezulu kunye nomyinge, umphumo ogcinwe ngokunciphisa i-ER-positive invasive cancer.

B)I-Exemestane yisizukulwana sesithathu esingenakuguquleka se-steroidal inactivator ye-enzyme ye-aromatase kwaye iyasebenza kuzo zonke izicwangciso zonyango lomhlaza webele, kubandakanywa ne-chemoprevention.

Kwimeko ye-metastatic, i-exemestane iphandwe ngokubanzi njengonyango lokuqala, umgca wesibini, kunye nonyango olungaphezulu kwaye ngoku ibhaliswe kunyango lwabasetyhini be-postmenopausal abanomdlavuza webele we-hormone-receptor-positive onesifo esiye saqhubela phambili emva kwe-antiestrogen. unyango.

Ingqalelo, ukungabikho kokuchasana okuphambeneyo kunye ne-NSAI kuvelisa amathuba ongezelelweyo kulandelelwano lonyango lwee-ejenti ze-endocrine.Ngaphezu koko, ngokusekelwe kwiziphumo ezinentsingiselo yeklinikhi, i-exemestane kunye ne-everolimus imele ukhetho olusebenzayo lonyango kwisifo esiye saqhubela phambili emva kokuvezwa kwi-NSAIs.

I-Exemestane ngokuqhelekileyo inyamezeleke kakuhle, kunye neprofayili yempembelelo efana neyezinye ii-AI kunye neempawu ze-menopausal, i-arthralgia, ukulahleka kwethambo, kunye nokuguqulwa kwe-lipid metabolism.


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