Iiteknoloji ezintsha
I-1) i-biotechnology: iteknoloji yobunjineli bemfuza, iteknoloji ye-biotransformation esebenzayo, iteknoloji ye-catalysis ye-industrial enzyme
I-2) I-Chemistry eluhlaza: ukusabela kwe-stereoselective, isisombululo se-reagent eluhlaza, inkqubo yokomeleza iteknoloji
Ubushushu bokusabela: – 100 ℃ ~ 150 ℃
Uxinzelelo lokusabela kwi-Hydrogenation: uxinzelelo lwe-atmospheri ~ 5 MPa
Iindidi zokusabela: Ukusabela kweGrignard, ukusabela kwe-hydrogenation, impendulo ekhethiweyo ye-redox, ukulungiswa ngokutsha, impendulo ye-witting, i-fluorination reaction, i-Foucault reaction, i-enzyme catalyzed reaction, njl.
Ngokukodwa, sinamava atyebileyo, imvelaphi yobuchwephesha kunye nobunjineli obuqinileyo kunye nesakhono sokukhulisa kwikhonkco ngalinye lokuhlolwa kwendlela yokwenziwa, ukuphuculwa kwenkqubo yophuhliso, ukukhulisa inkqubo kunye nokuphunyezwa.
Isiphumo: Ukuphucula ukusebenza kakuhle, ukunciphisa iindleko, kunye nokutshintsha imeko enzima yongcoliseko oluphezulu kunye nokusetyenziswa okuphezulu kwamandla.
Inkqubo yeMveliso yeeNdibaniselwano zeSteroidal
Iindlela eziqhelekileyo ziyi-chemical synthesis kunye nokuguqulwa kwe-microbial, apho ukuguqulwa kwe-microbial kudlala indima ebalulekileyo kuyo yonke inkqubo yokuvelisa.Owona mda mkhulu wendlela yokudityaniswa kwemichiza esetyenziswa kwikhompawundi ye-stereochemical ilele ekukhetheni kwayo kakubi.Ukuchaneka okuphezulu kokuchaphazeleka kwe-enzymatic okwenziwe yi-enzymes yebhayoloji kunokwenza ukusilela kweChemical Synthesis.Ukuqaliswa kwee-enzymes kwi-steroids kuye kwaguqulwa kwaba yimodeli efanelekileyo.
I-Microbial enzymatic catalysis kukuguqulwa kwenxalenye ethile (okanye iqela) ye-organic compound ibe kwenye ikhompawundi efana nesakhiwo.Imveliso yokugqibela yenguqu ayiveliswanga ngoluhlu lweenkqubo zemetabolism yeeseli zemicrobial, kodwa yenziwa ngokusabela kweekhemikhali zenxalenye ethile ye-substrate usebenzisa inkqubo ye-enzyme yeeseli ezincinci.Iinguqu ze-microbial reactions kwi-steroids zahlukene, kwaye zinamandla okuguqula i-athomu okanye amaqela kwindawo nganye ye-steroids, kubandakanya i-nucleus yomzali kunye namatyathanga asecaleni, kukho i-oxidation, ukunciphisa, i-hydrolysis, i-esterification, i-acylation, isomerization, i-halogenation, ukuvulwa kweringi, ukuthotywa kwekhonkco lecala.Ngamanye amaxesha i-microbe inokuphinda iphendule ngeendlela ezahlukeneyo kwi-steroid ngexesha elinye.I-Hydroxylation yenye yezona zinto zibalulekileyo kwi-microbial transformation ye-steroids.IiMicroorganisms zinokwenza i-hydroxylation reaction nakweyiphi na indawo ye-steroids, kodwa indlela yekhemikhali inzima ukwazisa i-hydroxyl kwezinye iindawo ngaphandle kwe-C-17.Ukuhlanganiswa kweekhemikhali kunye nokuguqulwa kwe-microbial yinkqubo esebenzayo yokuvelisa, ekhuthaza kakhulu ukuveliswa kwemveliso yeziyobisi ze-steroid.
Izinto eziluncedo kwezobuGcisa
1)Inkqubo epheleleyo yokuvundisa
2) Ukuqonda ukusetyenziswa kwetekhnoloji ye-chemical sybthesis eyahlukeneyo
3) Ukwenziwa kunye nophuhliso lwesicelo se-enzyme
4)Ukudibanisa okugqibeleleyo kokuguqulwa okuhlukeneyo
Ixesha lokuposa: Jul-08-2021