I-Dutasteride ithengiswa ngamachiza njengeAvodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost.Ngenxa yezizathu ezingaziwayo, ulingo lokuqala lweklinikhi lwe-dutasteride lwayekwa ngesiquphe ngo-2002, lwaze lwaqhubeka kamva.

I-Dutasteride yi-5-alpha-reductase inhibitor, oku kuthetha ukuba ivimbela isenzo se-5a-reducatse enzymes, ejongene ne-5a-ukunciphisa (ukuguqula) i-testosterone kwi-dihydrotestosterone (DHT) ngokudibanisa ibhondi ye-hydrogen ephindwe kabini.

I-Dutasteride inqanda zombini i-isoforms ye-5a-reductase, ngoko ke inqanda ukuguqulwa kwe testosterone kwi-dihydrotestosterone.Oku kwenza i-Dutasteride ibe lunyango olufanelekileyo lweNkndlalo yobudoda.Ngokuqinisekileyo, xa uguqula i-Testosterone encinci kwi-Dihydrotestosterone, unyusa amanqanaba e-testosterone ngokungagqibekanga (ukuguqulwa okuncinci).

I-Dutasteride, kwi-2.5mgs / imini iphantse ibe yi-1.5x isebenze ngakumbi kune-Finasteride kwi-5mgs / ngosuku, ekuphatheni ukulahleka kweenwele (zombini ukuyimisa kunye nokuyikhulisa kwakhona).Ukongezelela, i-Dutasteride ingasetyenziselwa ngempumelelo kwi-dose efanayo yokuphatha i-prostate ukwandiswa, kunye nesiphumo esincinci esaziwayo se-Dutasteride (kwakhona, kwi-dose efanayo) ukusetyenziswa kukunyanga i-Acne ebangelwa ubuninzi be-androgens emzimbeni.

Kuba i-steroid isebenzisa umgijimi ojongene nemiphumo echaphazelekayo ye-DHT, i-Dutasteride ingaba yimpendulo.Ukuchetywa kweenwele, iAne, kunye nokukhula kwedlala lobudoda konke (okunokwenzeka) kunokunqunyanyiswa ngokupheleleyo ngokusetyenziswa kwale mveliso.Ngelishwa, i-DHT ayisiyiyo yonke into embi, kwaye unokuphulukana nobulukhuni bemisipha (umgangatho we-amorphous ukuba kukho enye), kunye nezinye iimpawu esizithandayo kusetyenziso lwethu lwe-androgen.

Kwakhona ... kuba oku kuthintela kuphela i-5a-ukunciphisa i-androgens ephantsi kokuguqulwa kwifom ye-dihydro yabo ... ayinakwenza nto ukunqanda ukulahleka kweenwele okanye ezinye iimpawu ezibangelwa ngokupheleleyo kukusetyenziswa kwe-androgens kwintsapho ye-DHT.

I-Dutasteride, kunye ne-Finasteride yi-5-alpha-Reductase inhibitor eyiqela lamachiza aneempawu ezichasene ne-androgenic ezivimbela ukuguqulwa kwe-testosterone kwi-dihydrotestosterone (DHT).Le yikhemikhali efanayo efunyenwe kwiProscar kunye nePropecia kwaye isetyenziselwa unyango lwe-hyperplasia kunye ne-androgenic alopecia.Ngenxa yokuba la mayeza anciphisa amanqanaba e-dihydrotestosterone (DHT) asetyenziselwa ukuthintela kunye nokunyanga ukulahleka kweenwele.Idla ngokusetyenziswa ukunyanga amadlala edlala lengqula.